منابع مشابه
Cajal body finds its function
he Cajal body (CB, formerly coiled body) is a prominent nuclear structure, yet its function remains obscure. Now, speculate that the CB is where small nuclear RNAs go for modification. Last year, Kiss's team identified a small guide RNA, U85, that directs both 2'-O-methylation and pseudouridylation of the spliceosomal component U5 snRNA. This year, they've identified six more RNAs, Novel guide ...
متن کاملNew clues to the function of the Cajal body.
New clues to the function of the Cajal body Small RNA molecules play major roles in a number of cellular functions. Depending on their predominant cellular location, small RNAs have been classified as nuclear (sn), nucleolar (sno) or cytoplasmic (sc). The nucleoplasmic species include the spliceosomal snRNAs (U1, U2, U4, U5 and U6) and the U7 snRNA required for histone pre-mRNA 3′-end formation...
متن کاملOsterix finds its master.
Bone formation requires generation of osteoblasts from progenitor cells. it also depends on the ability of mature osteoblasts to synthesize bone extra cellular matrix (EcM). in osteoblasts, procollagen type i α1 and α2 chains are imported into the endoplasmic reticulum (Er), where they are post-translationally modified to form pro collagen triple helices. these are then secreted to form mature ...
متن کاملThe Cajal body and histone locus body.
The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs (scaRNAs). CBs contain high concentrations of splicing small nuclear ribonucleoproteins (snRNPs) and other RNA processing factors, suggesting that they are sites for assembly and/or posttranscriptional modification of the...
متن کاملThe Drosophila melanogaster Cajal body
Cajal bodies (CBs) are nuclear organelles that are usually identified by the marker protein p80-coilin. Because no orthologue of coilin is known in Drosophila melanogaster, we identified D. melanogaster CBs using probes for other components that are relatively diagnostic for CBs in vertebrate cells. U85 small CB-specific RNA, U2 small nuclear RNA, the survival of motor neurons protein, and fibr...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1577rr1